advantages and disadvantages of pharmaceutical packaging materials
Certain types of plastic, another commonly used material in pharmaceutical packaging, are reactive. Another packaging material used in the industry is metal, but glass and plastic are the most popular, and each has its advantages and disadvantages. subsequently cut & shaped (after reheating) by separate process. Further heating leads to the decomposition of the plastic. process & is The product is dropped into the pocket formed prior to Selecting the right type of packaging material to use is, therefore, crucial, especially if it is in direct contact with the product. All rights reserved. They are suitable for most acidic and neutral aqueous preparations whether parenteral or non- parenteral. This helps to: Increase pallet stability. The basic structure network of glass is silicon dioxide tetrahedron. Advantages The glass is most widely used packaging material. With a wide range of pharmaceutical products available on the market, both standard and bespoke packaging can be manufactured to meet product demands. Tubular Glassware: A tube of glass is first produced & Soda (NaCO3) 14 % Most plastic containers are usually not as clear as glass, and, therefore, inspection of the contents is impeded. Reduced leaching action. It should have sufficient mechanical strength so as to withstand handling, filling, closing and transportation. formed in general. More accurately control uniformity of glass distribution container. 1. finally stability at point of sale. Packaging Improves Medication Adherence Reports show that a significant percentage of people fail to take proper medications. It's More Biodegradable Than Other Materials. These are all advantages when exploring materials for pharmaceutical packaging. Disadvantages for a set time. Here we discuss how glass is used in pharmaceutical packaging and what benefits its use brings. Glass and plastic are well established primary packaging materials for the pharmaceutical industry but they both have their advantages and disadvantages. Review on: THE PHARMACEUTICAL PACKAGING | PharmaTutor Fin seal wrapper The average European generates 180kg of packaging waste annually, which could increase by 19% by 2030 without intervention. Can be grouped as: For injection and water for injection. It is common for glass to be colored to protect products from ultraviolet rays that can impact their function and efficacy. The packaging material used must be ideal to avoid any adverse reactions on the product and be good enough to protect the content. For medicine and pharmaceuticals, blister packaging can be completed with child safe features so only adults can open the packaging. Critical- hazardous to the user The primary packaging systemis the material that first envelops the product and holds it i.e., those package components and subcomponents that actually come in contact with the product, or those that may have a direct effect on the product shelf-life e.g., ampoules and vials, prefilled syringes, IV containers, blister packs, Bottles, and Sachet packaging etc. Pharmaceutical Packaging - pharmanotes.org Polyvinylchloride(PVC),Polystyrene Polypropylene, Nylon(PA), Composition 81% silicon dioxide; about 13% Boric oxide; & other oxide (Na & Al- non network forming oxide), Type I Most Highly Chemically resistant inert glass have high hydrolytic resistance due to the presence of. Glass and plastic are well established primary packaging materials for the pharmaceutical industry but they both have their advantages and disadvantages. This is a modified type of Type III glass container with a high hydrolytic resistance resulting fro m suitable treatment of the inner surface of a type III glass with sulfur. From temperature controlled solutions, to tamper evident tape and customs labelling, even the most delicate medicines can be shipped safely. Pharmaceutical packaging material plays a vital role in the stability of the pharmaceutical dosage form. Glass can also easily be sterilized and face high temperatures without denaturing, destroying bacteria and germs. Prefillable plastic syringes do not contain any tungsten left over from the production process and are made without any needle adhesive. Disadvantages Glass or PlasticA Question of Use - PharmTech This type of glass container has low hydrolytic resistance. is normalised in the lehr, where the whole container is raised to dull red heat Weight of metal packaging is low and its resistance is high. The final product was the result of pharmaceutical formulation and manufacturing processing expertise from Merck and Pfizer, in combination with Corning's . Blister packaging Although this is not a usually a problem, it can make things tricky for air sensitive medications, as the bottle is opened and closed multiple times throughout the day. Analytical and research services are always looking for ways to improve current pharmaceutical packaging methods. This secure form can make it difficult for some to open, especially those dealing with arthritis or other degenerative medical conditions. Aerosols, thermal shock or impact stress Tin is the most chemically inert of all collapsible metal tubes . They are cheap to manufacture Also read : Factors affecting Posology - Pharmaceutics - I B. Pharma 1st Semester They can be easily moulded or remoulded They have excellent finishing An L shaped sealer seals the over wrap Examples of thermoset resins include phenol formaldehyde (originally known as bakelite), urea formaldehyde, melamine formaldehyde, epoxy resins (expoxies), and certain polyesters and polyurethanes. Heat resistant. containers Ampoules Vials Disposable syringes Aerosols Types of containers of these containers prior to 1917, but after introduction of continuously drawing glass tube leads to greater use. With over 40 years experience, we have the knowledge and experience needed to recommend the very best solution for you. resistance packaging. The folded areas are sealed by pressing against a heated bar. Collapsible tubes used for packaging are constructed of metal, Product Identification:- Packaging greatly helps in It is a very economical material. 4. Glass containers can be easily sterilized using heat. Release alkali to aqueous preparation, Sand (silicon dioxide) Soda ash (sodium carbonate) Limestone Rubber closure with aluminum over cap used They are similar to glass syringes in terms of their functional properties such as break loose and gliding forces. Type 2: surface treated soda-lime glass. With extreme heat, it can melt or deform. What Are the Different Types of Pharmaceutical Packaging? WILL DEPEND UPON: Facilitating the use of product:- Packaging should be Because they must be kept in a cool location, it can be difficult to transport the medications. Most of these are made of aluminum . Advantages: Light, air and moisture resistant Stable at high and low temperature Non-toxic & odorless Disadvantages Easily dented and scratched Comparatively expensive PVC Foil Advantages: Inexpensive Light weight Ease of thermoforming Air proof Disadvantages: Poor heat stabile Poor barrier against moisture ingress PVDC Foil Advantages: Save my name, email, and website in this browser for the next time I comment. . These, if found in the plastic after polymerization are generally referred to as process residues. Both extremes indicate strain due to either tension or compression. Filtext is a cooperative of autonomous workers with a great human potential that, for more than 20 years, has as main objective to offer real solutions to companies in the territory that allow them to develop their work and allow us to diversify. Sachet packages are small pouch available in different shapes and sizes e.g: square and rectangle shapes. As glass is non-reactive, it is often chosen as the safest option. Put simply, tertiary solutions are used to protect both the product and packaging that sits beneath it during transportation. Example:- Strips, Blister, bottle, spray cane. It will not blacken them or harm them in any case. What are the types of packaging? efficacious appearance. Genesis Institute of Pharmacy, Radhanagari. Lower weight, It can also be difficult to take as needed, if you are not in a location with cooling capabilities. What are the different types of Pharmaceutical Packaging? 1. Packaging in the pharmaceutical industry varies from drug to drug and normally there are three levels of packaging commonly referred to as the primary, secondary, and tertiary packaging. package provides excellent environmental protection, and Packaging material is an important part of a pharmaceutical product. Type IHighly resistant borosilicate glass Do you have a review, update or anything you would like to add to this article? After studying Psychology and then Neuroscience, Sarah quickly found her enjoyment for researching and writing research papers; turning to a passion to connect ideas with people through writing. These materials are commonly used in the pharmaceutical industry as closures for glass and/or plastic containers, small cases as one time used for methanol cones, protective. The best blister packaging techniques are just one of the forms of vial pharmaceutical packaging available. You will find that the majority of over the counter medications and prescription medications come in a bottle. stress introduced in container during & immediately after glass 2023 MJH Life Sciences and Pharmaceutical Technology. finish. The benefits of aluminium foil in pharmaceutical packaging Can be classified as: It's pretty light. Your email address will not be published. creating glass disposable syringe. Organic coating and inks Poor printing, thermostatic charge, Thermosetting type They have low heat resistant and poor ductility. (oven) 540 oC Small bottles will probably withstand a temperature differential of 6080C, and 1 paints and lubricants. The same applies for pharmaceuticals under EU legislations. COP combines many of the properties of glass with the shatter-resistance of plastic, he points out. It's Easy to Recycle. This is a type of glass container that contains 80% silica, 10% boric oxide, small amount of sodium oxide and aluminium oxide. Advantages If the products have been treated with sulfites, aluminum is the material they need. It has high melting point so can with stand high temperatures. International Journal of Pharmacy and Pharmaceutical Sciences, 6(6), pp.480-485. Packaging should be such that it should maintain the integrity of the dosage form, should be inert in nature, should not be fragile, should have good mechanical strength. Ampoules, popular in 1920s & 1930s when first Think of it in this way, secondary packaging is used to protect the primary packaging, which is protecting the product. Bottling is also easier for coding identification purposes. Weights & Measures Act for dispensing records. 1. They are impermeable to light, moisture and gases. (2022, December 06). The disadvantages of Polyethylene Terephthalate as a material in plastic injection molding are: The material has lower heat resistance when compared to other polymers. Submission must include data on all packaging material constituents Ceramic Printing e.g. Introduction to glass,
Q. One of our key objectives is to increase the efficiency of drugs by ensuring that they are delivered in the most targeted and complete way possible. Secondary packaging system is outside the primary packaging and used to group primary packages together e.g., cartons, boxes, shipping containers, injection trays, etc. Because of its high elasticity, a feature unique to latex is its ability to be removed from a model like a glove. of a product from spoilage, breakage, leakage, etc. Pharmaceutical packaging plays a number of important roles when shipping sensitive and tightly regulated products. colours of red/bluegreater intensities of strain are indicated by colours The COP contact surface also improves the stability of highly sensitive medicines, such as the new generation of biopharmaceutical active ingredients, and minimizes the interaction between the drug and the packaging., For specific requirements, Gerresheimer has developed the multi-layer Gx MultiShell Vial made from COP and a polyamide barrier layer, says Friis. copper (cupric) oxide This package provide additional protection during warehousing and also provide information about drug product for e.g. This type of glass packaging is similar to type 2 glass, although it has not been treated and, therefore, does not have enhanced chemical resistance. We provide primary packaging for pharmaceutical products, food packaging, and stationery products. Primary packaging system is the material that first envelops the product and holds it i.e., those package components and subcomponents that actually come in contact with the product. The medical field has been playing an important role in everyones life not only in human life but also in the life of other living species. But, it does not have good oil and solvent resistance. At Swiftpak, we specialise in supplying the pharmaceutical market with industry-leading packaging solutions. Aerosol (Aerosols) is a self-Pressurized packaging form, consisting of a metal, glass, or plastic container with a permanently attached continuous or metering valve, and designed to dispense products as sprays, streams, gels, foams, lotions, or gases. PHARMACEUTICAL PACKAGING Peel able backing material is used to meet the requirements of child adhesive. form, Sorting & Inspection shape is achieved by one pressing of glass which is entrapped & What is primary packaging pharmaceuticals? Silica (SiO2), Do not sell or share my personal information. (approx) What Role Will The IoT Play In The Electric Vehicle Industry. Singh, A., Sharma, P. and Malviya, R., 2011. Glass has many benefits as a pharmaceutical packaging material. 3. pharmaceutical products. They are attractive in nature cylindrical bottle with near flat shoulders Advantages : Oil resistant due to polar nitrile group. submit data on packaging materials & components to FDA prior to Cooling Get the latest offers and news in our weekly update, Swiftpak Limited Arrowhead Road Theale, Reading RG7 4AH England, By clicking "Submit" you agree for us to contact you for marketing purposes using information you have provided. A proper choice of the vial itself can therefore be decisive for the success and the profitability of a freeze-drying cycle. Which is often achieved through primary, secondary and tertiary packaging. Essentially chemically inert, impermeable, strong and rigid. Laboratory organization, management and safety methods - Chapter # 03 : LABOR Vitrification and it's use in treating hazardous waste, obstructive sleep apnoea and hypopnea syndrome.pptx, 6 Disorders of the lacrimal system Oghre.pptx, Urine Collection Preservation Pre analytical errors.pptx, Hormonal regulation of blood glucose level_pdf.pdf, Material Owned and operated by AZoNetwork, 2000-2023. They provide the same benefits of bottled medications, but solve the problem of storing air or temperature resistant medications. used. Composed of silicon dioxide & high proportional of Sodium oxide (14%) & Calcium oxide (18%). flexible But are you aware of the different types and their purpose? Tamper resistant package is one having an indicator to entry in A tertiary packaging system is used for bulk handling and shipping e.g., barrel, container, edge protectors, etc. Type IV NP Soda glass (Non-parenteral use) The information and guidance mentioned over the packaging should be mentioned in detail, clear, and readable which would make packaging looking more effective and trustworthy. packaging: Film wrappers, Blister package, Strip package, compactable and limited protection of plastic. Thermosets usually contain additional additives (fillers and reinforcing agents) to obtain best quality. Moore, Sarah. strength plus an external coating of PVC Casting uses gravity or centrifugal force to cause molten glass Stretch Wrap is a product used to secure goods on a pallet for storage or transportation by simply wrapping a stretchable plastic film around the products. The metals commonly used for this purpose are aluminium ,tin plated steel, stainless steel, tin and lead. Typically glassine liners are two ply laminations use in two It is very fragile to the blows and that can hinder its transport. Here, we try to mention the advantages and disadvantages of commonly used pharmaceutical packaging materials -. What are the different types of Pharmaceutical Packaging? Pharmaceutical Packaging: Pharmaceutical packaging means the combination of components necessary to contain, preserve, protect & deliver a safe, efficacious drug product, such that at . The most common methods are useful and provide good storage to medications, but still have their disadvantages. shape of the container. may be used. For more detail about our products and services you can reach us at uniworthllp.com. glass & occasionally in treated soda glass. Commonly used pharmaceutical packaging materials include glass bottle, plastic bottle, aluminum foil etc. Winchesters: widely used in UK & covers range from The package external to Primary package is known as secondary package. inorganic product of fusion that has been cooled to a It is capable of mixing and homogenizing powders and suspensions with a frequency of 30 Hz within seconds. The blister package is formed by heat softening a sheet of Blister packaging may also be more child proof friendly than other types of vial pharmaceutical packaging methods. so, the outer look and packaging of the product play an important role, the pharmaceutical packaging is not just about attracting or convincing people to purchase the medicine but a lot more. Glass bottles cost more than metal cans but offer good Dirt, dope, adhering particles or oil marks Type II containers are made of commercial soda lime glass that After cooling the sheet is released from the mold and proceeds to the Others include nylon, polyvinylidene chloride, polycarbonate etc.. Thermoplastics may be further classified into homopolymers which involves one type of monomers, e.g., ethylene polymerized to polyethylene, and copolymers, terpolymers etc., which involve two or more monomers of different chemical substances. This helps to: To put things bluntly, there is no one-size-fits-all approach when it comes to pharmaceutical packaging. be destroyed to obtain the product. A group of non-metallic substances, of natural, semi-synthetic or synthetic origins, consisting chiefly of one or more organic compounds (polymer) of high molecular weight, which can be moulded into the desired shapes and hardened for use when subjected to heat or pressure, with or without the addition of some additives. lacquers and enamels as applied internally and externally to metal containers and a range of adhesive systems. The valves are set in an aluminum over seal. It does not support corrosive materials. Additionally, bottles do not provide any type of medication tracking system, making it difficult to remember if and how many a person has taken of that specific drug throughout the day. lime glass Type II Treated Soda lime glass (surface treatment) It should not leach alkali in the contents. formaldehyde (MF), Epoxy resins (epoxides), Polyurethanes (PURs) Infusion fluids, blood sheet of glassine paper bounded together with wax or adhesive The pharmaceutical industry has used glass to produce safe and secure packaging for its vast array of products for many decades. Ex. Temperature sensitive bottles Forming, Pressed Glassware: It involve first step of above process & the final When a glass bottle leaves a mould the outside tends to cool more rapidly The bottles are also made with child proof features, making them difficult for young children to open, but simple for adults to open, regardless of their medical restrictions. paper/polyethylene/foil/PVC. An optimised tertiary packaging solution should look to combine products as tightly and compact as possible, while using minimal materials and without causing strain or damage to products. Advantages so it should be avoided. Primary packaging materials for pharmaceutical freeze-drying: Moulded For example, glass is not only tough and durable, but it can also be easily labeled and molded into bespoke shapes and sizes. concave base with variety of neck finishes in various convenience to open, handle and use for the Thanks to its superior barrier properties, aluminium foils remains the material of choice for pharma. Packaging, involves two basic considerations Injection vials are obtained in either neutral or soda 8/Pharmacognosy and Phytochemistry/post-list, Pathophysiology - B. Pharma 2nd Semester notes pdf, PHARMACOLOGY & TOXICOLOGY D. Pharm 2nd year PDF Notes, D. Pharmacy Notes | D. Pharma Notes | Study material Diploma in Pharmacy pdf, Drug Store and Business Management - D. Pharma 2nd Year Notes, Pharmaceutical Jurisprudence - PDF notes & Important Question Answer, Industrial Pharmacy (Theory) - B. Pharma 5th Semester PDF Notes, B. Pharma Notes | B. Pharma Notes | Study material Bachelor of Pharmacy pdf, Hospital Clinical Pharmacy - D. Pharma 2nd Year Notes, PHARMACEUTICAL CHEMISTRY II - D. Pharm 2nd Year Short Notes, Stroke - B. Pharma 2nd Semester Pathophysiology notes pdf. Tubular glass containers, use of ampoule is vary static. Youve been successfully subscribed to our newsletter! We use cookies to enhance your experience. Filling method Pharmaceuticals are a billion dollar industry in the United States. together the two inside surfaces of the film, producing a fin Packaging plays an important role in preserving the stability and quality of pharmaceutical products so that they are safe and effective when patients use them. capacities. identification of products. Comparison of environmental sustainability of pharmaceutical packaging Narrow Neck Press & Blow (NNPB), of the glass in order to strengthen the container. 2. Glass Defects, test In contrast to glass, plastic is shatterproof and lightweight and can be made flexible, soft, or hard depending on the requirements-a versatility that glass cannot offer, notes Jens Friis, vice-president, Europe & Latin America Plastic Packaging, Gerresheimer. Which Metals are popular in pharmaceutical packaging? has been dealkalized or treated to remove surface alkali Metal is suitable for protecting food contents, as it is commonly fabricated to be tamperproof in its container form. synthetic origins, consisting chiefly of polymers of high molecular The seals are formed by crimping the film together and sealing Almost the softening point Image Credit:Dmitry Kalinovsky/Shutterstock.com. These medications also expire rather quickly, not making them ideal for medication that is not used frequently. Siddhivinayak Towers, Near Kataria Arcade, Off. When choosing the appropriate plastic container, it is important to consider whether the drug is solid or liquid and how it is dispensed, taken, or administered, he says. It is opaque and impervious to gases and vapors. Aesthetic appeal: Consumer convenience. Vertical load test
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